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IAP Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S7025 Embelin Embelin (Embelic Acid, NSC 91874), a quinone isolated from the Japanese Ardisia herb, is an inhibitor of X-linked inhibitor of Apoptosis (XIAP) with IC50 of 4.1 μM in a cell-free assay.
Heliyon, 2023, 9(3):e14006
Cancers (Basel), 2021, 13(14)3585
Cell Host Microbe, 2018, 24(5):689-702
Verified customer review of Embelin
S5967 Berberine chloride hydrate Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.
Front Biosci (Landmark Ed), 2022, 27(8):242
Front Pharmacol, 2021, 12:632201
S9634 Phenoxodiol (Haginin E) Phenoxodiol (Haginin E, Idronoxil, Dehydroequol, NV 06, PXD) is an isoflavone analog with antineoplastic activity. It activates the caspase system, inhibits XIAP (X-linked inhibitor of apoptosis), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumour cell apoptosis. This compound also inhibits DNA topoisomerase II.
Anticancer Res, 2018, 38(10):5709-5716
S5600 Flavokawain A Flavokawain A, extracted from kava, is an apoptotic inducer and anticarcinogenic agent. This compound can down-regulate antiapoptotic proteins, such as XIAP, survivin, and Bcl-xL, thereby changing the balance between apoptotic and antiapoptotic molecules and then inducing cell death in tumour cells.