Histone Acetyltransferase Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S1242	CPTH2	CPTH2 is a potent histone acetyltransferase (HAT) inhibitor modulating Gcn5p network. This compound induces apoptosis and decreases the invasiveness of a ccRCC cell line through the inhibition of KAT3B.	Transl Oncol, 2021, 14(11):101196
E1107	CTB	CTB is a p300 activator and the lowest docked energy for this compound and p300 is 7.72 kcal/mol.
S7475	NU9056	NU9056 is a potent and selective inhibitor of Tip60 (KAT5) histone acetyltransferase with an IC50 value of 2 µM. This compound demonstrates over 16-fold selectivity for Tip60 compared to PCAF, p300, and GCN5 and effectively induces apoptosis in prostate cancer cells.
S6655	WM-8014	WM-8014 is a highly potent inhibitor of histone acetyltransferase KAT6A with an IC50 of 8 nM.
E6080^New	AUR1545	AUR1545 is a potent and selective degrader of KAT2A and KAT2B. It exhibits an anti-proliferative effect and significantly inhibits tumour growth in an NCI-H1048 xenograft model.
E5885^New	JG-2016	JG-2016 is a potent and selective inhibitor of HAT1, with an IC50 of 14.8 μM and a binding KD of 22.5 μM for the HAT1:Rbap46 complex. It exhibits anti-proliferative activity with EC50 of 10.4 μM, 29.8 μM, and 1.9 μM in HCC1806, FICC1937, and A549 cells, respectively. JG-2016 significantly suppresses tumour growth in an A549 xenograft model.
E5829^New	PU139	PU139 is a potent inhibitor of pan-histone acetyltransferase (HAT) that blocks Gcn5, PCAF, CBP, and p300 with IC50 values of 8.39 μM, 9.74 μM, 2.49 μM, and 5.35 μM, respectively. It significantly impairs Smp14 promoter activity, suggesting that targeting SmGCN5 and SmCBP1 is a novel strategy to control S. mansoni egg development, it also exhibits anticancer activity.
E0068	NiCur	NiCur is a small molecule which blocks CREB-binding protein (CBP) Histone Acetyltransferase (HAT) activity and downregulates p53 activation upon genotoxic stress and diminishs the recruitment of p53 as well as RNA Polymerase II and levels of acetylation on histone H3 on CDKN1A promoter.
E1387	Butyrolactone 3	Butyrolactone 3 is a non-irreversible inhibitor of the histone acetyltransferase Gcn5, with an IC50 of 100 μM. It selectively targets the Gcn5/PCAF family exhibiting weak inhibition of CBP HAT with an IC50 of 0.5 mM and also inhibits pre-mRNA splicing in vitro before catalysis, with an IC50 of 0.5 mM.
E7170	KAT8-IN-1	KAT8-IN-1 is an inhibitor of lysine acetyltransferase 8 (KAT8) with IC50 values of 141 μM, 221 μM and 106 μM for KAT8, KAT2B, KAT3B respectively. By inhibiting histone acetyltransferases (HATs), it helps investigate their role in disease and holds potential as a therapeutic agent for cancer and inflammatory conditions.
E5782	Remodelin	Remodelin is a potential inhibitor of the acetyltransferase NAT10. It enhances nuclear shape and cellular fitness in both progeric cells and cells depleted of Lamin A/C by inhibiting NAT10. This compound exhibits anti-proliferation activity and significantly inhibits tumour growth and tumour cell proliferation in the PDX model of HNSCC.
S1848	Curcumin	Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase (IC50~25 μM) and Histone deacetylase (HDAC); activates Nrf2 pathway and suppresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the Influenza Virus, hepatitis C virus, HIV and so on.	J Biol Chem, 2025, 301(7):110305 Mol Pain, 2025, 21:17448069251323668 BMC Immunol, 2025, 26(1):67
S7256	SGC-CBP30	SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively.	Mol Cell, 2025, 85(8):1525-1542.e10 Cell Death Dis, 2025, 16(1):193 Cell Rep, 2025, 44(4):115523
S7582	Anacardic Acid	Anacardic Acid (6-pentadecylsalicylic Acid) is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity, prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.	Sci Adv, 2025, 11(9):eadq2881 J Transl Med, 2024, 22(1):995 Int J Mol Sci, 2024, 25(17)9600
S9648	NEO2734 (EP31670)	NEO2734 (EP31670) is a novel, orally active and selective dual inhibitor of p300/CBP and BET bromodomain with IC50 of both <30 nM.	Cell Rep Med, 2024, 5(3):101471 Nat Cancer, 2023, 4(10):1508-1525 PLoS Pathog, 2023, 19(8):e1011598
S9432	Ginkgolic Acid	Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit Histone Acetyltransferase (HAT).	Microbiologyopen, 2025, 14(4):e70038 Pharmaceutics, 2024, 16(5)638 CNS Neurosci Ther, 2022, 10.1111/cns.13871
S8190	CPI-637	CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor with IC50 values of 0.03 μM and 0.051μM for CBP and EP300 respectively in TR-FRET assay. It is highly selective against other bromodomains, displaying substantial biochemical activity only against BRD9.	Mol Cell Proteomics, 2023, 22(3):100504 Acta Pharmacol Sin, 2019, 10.1038/s41401-019-0237-5
S1161	Histone Acetyltransferase Inhibitor II	Histone Acetyltransferase Inhibitor II (HAT Inhibitor II, compound 2c) is a potent, selective and cell-permeable p300 histone acetyltransferase (HAT) inhibitor with IC50 of 5 μM. Histone Acetyltransferase Inhibitor II shows anti-acetylase activity in mammalian cells.	Genetics, 2017, 205(3):1125-1137
S6876	CPI-1612	CPI-1612 is a highly potent, orally active inhibitor of EP300/CBP histone acetyltransferase (HAT). It displays an IC50 of 8.0 nM for EP300 HAT. CPI-1612 suppresses H3K27 acetylation in vivo and exhibits efficacy in JEKO-1 mantle cell lymphoma xenograft at a low dose. CPI-1612 displays anticancer activity.
S6886	1-Aminobenzotriazole	1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. This compound is also a substrate and inhibitor of N-acetyltransferase (NAT).
S9445	Ginkgolic Acid (C13:0)	Ginkgolic Acid (C13:0), a natural anticariogenic agent in Ginkgo biloba L., exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity. This compound is a potent sumoylation inhibitor and reported to inhibit Histone Acetyltransferase (HAT).