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Chloride Channel Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S1203 T16Ainh-A01

T16Ainh-A01 is a potent and selective inhibitor of calcium-activated chloride channel (CaCC)/transmembrane protein 16A (TMEM16A, ANO1) with IC50 of 1.8 μM.
S8279 (±)-Shikonin (±)-Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A Chloride Channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via Proteasome inhibition.
Signal Transduct Target Ther, 2025, 10(1):341
J Exp Clin Cancer Res, 2025, 44(1):299
Free Radic Biol Med, 2025, 237:65-75
S6439 Talniflumate Talniflumate (MSI-1995) is an anti-inflammatory molecule studied and used as a mucin regulator in the treatment of cystic fibrosis, chronic obstructive pulmonary disease (COPD) and asthma. This compound is also an inhibitor of human calcium-activated Chloride Channel.
Toxicol Lett, 2025, 406:31-37
Acta Pharm Sin B, 2023, 13(2):662-677
S4339 Meticrane Meticrane is a diuretic that inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule. This compound is used to treat essential hypertension.
S6470 Fluralaner Fluralaner (A1443, AH252723) is a systemic insecticide and acaricide that is administered orally. This compound inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) and L-glutamate-gated chloride channels (GluCls)