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GSK-3β-Sélectif Inhibitors

  • GSK-3α
  • GSK-3β
N° de cat. Nom du produit Informations Sélectif / Pan IC50 / Ki
S7193 1-Azakenpaullone 1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25. Selective GSK-3β, IC50: 18 nM
S1590 TWS119 TWS119 is a GSK-3β inhibitor with IC50 of 30 nM; capable of inducing neuronal differentiation and may be useful to stem cell biology. Selective GSK-3β, IC50: 30 nM
S7435 AR-A014418 AR-A014418 is an ATP-competitive, and selective GSK3β inhibitor with IC50 and Ki of 104 nM and 38 nM, without significant inhibition on 26 other kinases tested. Selective GSK-3β, Ki: 38 nM; GSK-3β, IC50: 104 nM; GSK-3β, Ki: 38 nM; GSK-3β, IC50: 104 nM; GSK-3β, Ki: 38 nM; GSK-3β, IC50: 104 nM; GSK-3β, Ki: 38 nM; GSK-3β, IC50: 104 nM; GSK-3β, Ki: 38 nM; GSK-3β, IC50: 104 nM
S7566 IM-12 IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling. Selective GSK-3β, IC50: 53 nM
S2823 Tideglusib Tideglusib is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2. Selective GSK-3β, IC50: 60 nM
S2386 Indirubin Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM. Selective GSK-3β, IC50: 0.6 μM
S2926 TDZD-8 TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC. Selective GSK-3β, IC50: 2 μM
S2745 CHIR-98014 CHIR-98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2. Pan GSK-3β, IC50: 0.58 nM
S7063 LY2090314 LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. Phase 2. Pan GSK-3β, IC50: 0.9 nM
S2924 CHIR-99021 (CT99021) HCl CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; ability to distinguish between GSK-3 and its closest homologs Cdc2 and ERK2. Pan GSK-3β, IC50: 6.7 nM
S7145 AZD1080 AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against CDK2, CDK5, CDK1 and Erk2. Pan GSK-3β, IC50: 31 nM
S1075 SB216763 SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3α and equally effective at inhibiting human GSK-3β. Pan GSK-3β, IC50: ~34.3 nM
S2729 SB415286 SB415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β. Pan GSK-3β, IC50: ~78 nM