Mitochonic acid 5 (MA-5)

Catalog No.S0881 Batch:S088102

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Technical Data

Formula

C18H13F2NO3
Molecular Weight 329.30 CAS No. 1354707-41-7
Solubility (25°C)* In vitro DMSO 66 mg/mL (200.42 mM)
Water Insoluble
Ethanol Insoluble
In Vivo (Add solvents to the product individually and in order.)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Mitochonic acid 5 (MA-5) reduces mitochondrial apoptosis via upregulation of mitophagy, regulates mitophagy via Bnip3 through the MAPK-ERK-Yap signalling pathway, and modulates mitochondrial ATP synthesis.
Targets
mitophagy Bnip3

Protocol (from reference)

References

  • https://pubmed.ncbi.nlm.nih.gov/29636771/
  • https://pubmed.ncbi.nlm.nih.gov/26609120/

Sellecks Mitochonic acid 5 (MA-5) Has Been Cited by 6 Publications

Mitochonic acid 5 increases boar sperm quality by mitigating mitochondrial dysfunction [ Front Cell Dev Biol, 2025, 13:1583951] PubMed: 40589524
Mitochonic Acid 5 Increases Ram Sperm Quality by Improving Mitochondrial Function during Storage at 4° C [ Animals (Basel), 2024, 14(3):368.] PubMed: 38338011
Mitochonic Acid 5 Increases Ram Sperm Quality by Improving Mitochondrial Function during Storage at 4 °C [ Animals (Basel), 2024, 14(3)368] PubMed: 38338011
UBE2T regulates epithelial-mesenchymal transition through the PI3K-AKT pathway and plays a carcinogenic role in ovarian cancer [ J Ovarian Res, 2022, 15(1):103] PubMed: 36088429
Mitochonic acid 5 regulates mitofusin 2 to protect microglia [ Neural Regen Res, 2021, 16(9):1813-1820] PubMed: 33510088
Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy [ Cell Mol Biol Lett, 2018, 23:14] PubMed: 29636771

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.