Methazolamide

Catalog No.S4039 Batch:S403901

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Technical Data

Formula

C5H8N4O3S2
Molecular Weight 236.27 CAS No. 554-57-4
Solubility (25°C)* In vitro DMSO 47 mg/mL (198.92 mM)
Ethanol 3 mg/mL (12.69 mM)
Water Insoluble
In Vivo (Add solvents to the product individually and in order.)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Methazolamide (CL 8490) is a Carbonic Anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
Targets
hCAII bCAIV hCAI
14 nM(Ki) 36 nM(Ki) 50 nM(Ki)
In vitro Methazolamide is a Carbonic Anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively. This compound is of strength equal to acetazolamide, another Carbonic Anhydrase inhibitor used to treat irregular breathing disorders. However, this chemical differs from acetazolamide in that it fails to activate Ca2+-dependent potassium channels in skeletal muscles.
In Vivo Methazolamide does not impair respiratory work performance in anesthetised rabbits.
Features Methazolamide potently inhibits various isoforms of Carbonic Anhydrase.

Protocol (from reference)

References

  • http://www.ncbi.nlm.nih.gov/pubmed/?term=12617904
  • http://www.ncbi.nlm.nih.gov/pubmed/?term=19553495
  • http://www.ncbi.nlm.nih.gov/pubmed/?term=4960944

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.