Puerarin

Catalog No.S2346 Batch:S234601

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Technical Data

Formula

C21H20O9
Molecular Weight 416.38 CAS No. 3681-99-0
Solubility (25°C)* In vitro DMSO 86 mg/mL (206.54 mM)
Water Insoluble
Ethanol Insoluble
In Vivo (Add solvents to the product individually and in order.)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Puerarin (Kakonein), an isoflavone found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist.
In vitro Puerarin (Kakonein), an isoflavone found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist. This compound is employed clinically to treat cardiovascular diseases in China. Another study showed that this chemical also possessed anti-cancer properties. It at 25 μM dose-dependently reduces HT-29 cellular growth with an increase of bax and decreases of c-myc and bcl-2.
In Vivo In hypercholesterolemic diet plus administration of Puerarin (300 mg/kg/day, p.o.) rats, this compound markedly attenuated the increased total cholesterol induced by hypercholesterolemic diet in both serum and liver. LD50: Mice 738mg/kg (i.v.)

Protocol (from reference)

References

  • https://pubmed.ncbi.nlm.nih.gov/12895679/
  • https://pubmed.ncbi.nlm.nih.gov/16472823/
  • https://pubmed.ncbi.nlm.nih.gov/16055262/

Sellecks Puerarin Has Been Cited by 9 Publications

Puerarin inhibits NHE1 activity by interfering with the p38 pathway and attenuates mitochondrial damage induced by myocardial calcium overload in heart failure rats [ Acta Biochim Biophys Sin (Shanghai), 2024, 56(2):270-279] PubMed: 38282474
Puerarin Prevents Cadmium-Induced Neuronal Injury by Alleviating Autophagic Dysfunction in Rat Cerebral Cortical Neurons [ Int J Mol Sci, 2023, 24(9)8328] PubMed: 37176033
Puerarin alleviates cadmium-induced rat neurocyte injury by alleviating Nrf2-mediated oxidative stress and inhibiting mitochondrial unfolded protein response [ Ecotoxicol Environ Saf, 2022, 247:114239] PubMed: 36326556
Puerarin attenuates cisplatin-induced apoptosis of hair cells through the mitochondrial apoptotic pathway [ Biochim Biophys Acta Mol Cell Res, 2022, S0167-4889(21)00262-7] PubMed: 35032475
Puerarin Restores Autophagosome-Lysosome Fusion to Alleviate Cadmium-Induced Autophagy Blockade via Restoring the Expression of Rab7 in Hepatocytes [ Front Pharmacol, 2021, 12:632825] PubMed: 33935722
Role of Flavonoids in the Prevention of AhR-Dependent Resistance During Treatment with BRAF Inhibitors [ Int J Mol Sci, 2020, 21(14):5025] PubMed: 32708687
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] PubMed: 30900754
Puerarin Decreases Collagen Secretion in AngII-Induced Atrial Fibroblasts Through Inhibiting Autophagy Via the JNK-Akt-mTOR Signaling Pathway. [ J Cardiovasc Pharmacol, 2019, 73(6):373-382] PubMed: 31162246
Colloidal Aggregation and the in vitro Activity of Traditional Chinese Medicines. [Duan D, et al. ACS Chem Biol, 2015, 10.1021/cb5009487] PubMed: 25606714

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.