Hexestrol

Catalog No.S2473 Batch:S247301

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Technical Data

Formula

C18H22O2
Molecular Weight 270.37 CAS No. 84-16-2
Solubility (25°C)* In vitro DMSO 42 mg/mL (155.34 mM)
Ethanol 42 mg/mL (155.34 mM)
Water Insoluble
In Vivo (Add solvents to the product individually and in order.)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Hexestrol (Bibenzyl) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
Targets
ERα ERβ
0.07 nM(EC50) 0.175 nM(EC50)
In vitro Hexestrol binds to ERα with EC50 of 0.07 nM and to ERβ with EC50 of 0.175 nM. This compound inhibits activity of AKR1B13 with IC50 of 3.2 μM. It inhibits the d-galactose dehydrogenase activity of thermophilus aldose 1-dehydrogenase with IC50 of 0.063 mM. This chemical inhibits the dehydrogenase activity of AKR1C20 towards 10 μM 4-androsten-3α-o1-17-one with IC50 values of 2.7 μM. It inhibits 17HSD5 with IC50 of 30 μM, and inhibits TBER1 with IC50 of 0.8 μM. This compound reacts with DNA through the catechol quinone, thus can be a carcinogen.
In Vivo Hexestrol administered intraperitoneally at a dose of 6 mg/kg may decrease ovulation in mice, as evident by smaller ovaries and decreased luteal bodies and oocytes.
Features Much higher ERβ binding selectivity than Erα.

Protocol (from reference)

Animal Study:[7]
  • Animal Models

    adult mice aged 90-120 days

  • Dosages

    3 mg/kg and 6 mg/kg

  • Administration

    administered intraperitoneally once daily for 30 days

References

  • https://pubmed.ncbi.nlm.nih.gov/19286283/
  • https://pubmed.ncbi.nlm.nih.gov/18845131/
  • https://pubmed.ncbi.nlm.nih.gov/18926808/
  • https://pubmed.ncbi.nlm.nih.gov/16508162/
  • https://pubmed.ncbi.nlm.nih.gov/16788056/
  • https://pubmed.ncbi.nlm.nih.gov/15650250/

Sellecks Hexestrol Has Been Cited by 2 Publications

Optimized reporters for multiplexed detection of transcription factor activity [ Cell Syst, 2024, 15(12):1107-1122.e7] PubMed: 39644900
Patient-derived rhabdomyosarcoma cells recapitulate the genetic and transcriptomic landscapes of primary tumors [ iScience, 2024, 27(10):110862] PubMed: 39319271

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.